An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1

J Antimicrob Chemother. 2001 Nov;48(5):627-30. doi: 10.1093/jac/48.5.627.


An extended-spectrum beta-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. bla(IBC-2) was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these beta-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-beta-lactams.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Ceftazidime / pharmacology
  • Cephalosporins / pharmacology
  • DNA Transposable Elements / genetics*
  • Escherichia coli / genetics
  • Humans
  • Molecular Sequence Data
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / genetics*
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / chemistry
  • beta-Lactamases / genetics*


  • Cephalosporins
  • DNA Transposable Elements
  • Ceftazidime
  • GES-1 beta-lactamase
  • integron-associated beta-lactamase 1
  • beta-Lactamases

Associated data

  • GENBANK/AF329699