Palatal development in Twirler mice

Cleft Palate Craniofac J. 2001 Nov;38(6):622-8. doi: 10.1597/1545-1569_2001_038_0622_pditm_2.0.co_2.


Objective: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted.

Results and conclusions: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cephalometry
  • Cleft Palate / embryology*
  • Coloring Agents
  • Disease Models, Animal
  • Embryo, Mammalian
  • Embryonic and Fetal Development
  • Eosine Yellowish-(YS)
  • Fluorescent Dyes
  • Gestational Age
  • Hematoxylin
  • Homozygote
  • Image Processing, Computer-Assisted
  • Mice
  • Mice, Mutant Strains
  • Palate / embryology*
  • Skull / embryology
  • Statistics as Topic


  • Coloring Agents
  • Fluorescent Dyes
  • Eosine Yellowish-(YS)
  • Hematoxylin