HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

FEBS Lett. 2001 Oct 19;507(1):39-44. doi: 10.1016/s0014-5793(01)02945-3.


Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA, Viral / genetics
  • DNA, Viral / metabolism
  • HIV Integrase / chemistry
  • HIV Integrase / metabolism*
  • HIV Integrase Inhibitors / metabolism
  • HIV Long Terminal Repeat
  • HIV Reverse Transcriptase / chemistry
  • HIV Reverse Transcriptase / metabolism*
  • HIV-1 / enzymology*
  • HIV-1 / genetics
  • HIV-1 / physiology
  • Humans
  • Reverse Transcriptase Inhibitors / metabolism
  • Virus Replication / physiology


  • DNA, Viral
  • HIV Integrase Inhibitors
  • Reverse Transcriptase Inhibitors
  • HIV Integrase
  • HIV Reverse Transcriptase