The neutral theory in the genomic era

Curr Opin Genet Dev. 2001 Dec;11(6):642-6. doi: 10.1016/s0959-437x(00)00247-1.


A number of tests have been developed to detect positive selection at the molecular level. These tests are based on DNA polymorphism within and divergence between species. Applications of these tests have revealed a large collection of genes that have evolved under positive selection and some general insights into adaptive evolution. Recently, these tests have been applied on a genomic scale and have provided estimates of the frequency of adaptive substitutions and a critical test of the neutral theory.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila / genetics
  • Evolution, Molecular*
  • Gene Frequency
  • Genetic Variation* / genetics
  • Polymorphism, Genetic*
  • Selection, Genetic