Insights from linked single nucleotide polymorphisms: what we can learn from linkage disequilibrium

Curr Opin Genet Dev. 2001 Dec;11(6):647-51. doi: 10.1016/s0959-437x(00)00248-3.


New methods for analyzing sequence polymorphism data have uncovered some striking patterns of linkage disequilibrium in both humans and fruitflies. These methods have revealed examples where the observed amount of linkage disequilibrium is either much more or much less than expected, and have led to advances in our understanding of the forces that affect naturally occurring genetic variation. With the recent explosion of sequence polymorphism data, the prospects for further progress from these methods are quite promising.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alleles
  • Animals
  • Drosophila / genetics
  • Gene Conversion
  • Genetic Variation*
  • Genetics, Population
  • Genome, Human
  • Humans
  • Linkage Disequilibrium / genetics*
  • Polymorphism, Single Nucleotide*
  • Recombination, Genetic / genetics