Evolution of novel genes

Curr Opin Genet Dev. 2001 Dec;11(6):673-80. doi: 10.1016/s0959-437x(00)00252-5.


Much progress in understanding the evolution of new genes has been accomplished in the past few years. Molecular mechanisms such as illegitimate recombination and LINE element mediated 3' transduction underlying exon shuffling, a major process for generating new genes, are better understood. The identification of young genes in invertebrates and vertebrates has revealed a significant role of adaptive evolution acting on initially rudimentary gene structures created as if by evolutionary tinkers. New genes in humans and our primate relatives add a new component to the understanding of genetic divergence between humans and non-humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Exons / genetics
  • Gene Duplication
  • Genes*
  • Humans
  • Mutagenesis
  • Proteins / genetics
  • Recombination, Genetic
  • Retroelements


  • Proteins
  • Retroelements