Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways

J Cell Sci. 2001 Jul;114(Pt 14):2553-60.

Abstract

Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Division / physiology
  • Cyclin-Dependent Kinases / metabolism*
  • Cytoplasm / enzymology
  • Humans
  • Integrins / metabolism*
  • Mammals
  • Signal Transduction / physiology*

Substances

  • Integrins
  • Cyclin-Dependent Kinases