Clearing the brain's amyloid cobwebs

Neuron. 2001 Oct 25;32(2):177-80. doi: 10.1016/s0896-6273(01)00475-5.


Elevated cerebral levels of amyloid beta-protein occur universally in Alzheimer's disease, yet only a few patients show evidence of increased Abeta production. Therefore, defects in proteases that degrade Abeta could underlie some or many cases of familial and sporadic AD. This previously neglected topic has begun receiving serious attention. Understanding how proteolysis regulates Abeta levels in the cerebral cortex has implications for both the pathogenesis and the treatment of this protean disorder.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / enzymology
  • Alzheimer Disease / genetics
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Brain / enzymology*
  • Endopeptidases / genetics
  • Endopeptidases / metabolism*
  • Humans
  • Insulysin / metabolism
  • Mutation
  • Neprilysin / metabolism


  • Amyloid beta-Peptides
  • Endopeptidases
  • Neprilysin
  • Insulysin