Emerging roles for chromatin remodeling in cancer biology

Trends Cell Biol. 2001 Nov;11(11):S15-21. doi: 10.1016/s0962-8924(01)02125-0.

Abstract

Cell proliferation and differentiation are guided by changes in gene expression and require the coordinated efforts of the transcription machinery and chromatin-remodeling factors. However, aberrant regulation of chromatin structure can arise through mutations in chromatin-modifying and -remodeling proteins and can lead to improper gene expression and cancer. This review discusses how mutations in chromatin regulators might affect their targeting or activity, with an emphasis on the important insights revealed by leukemogenic fusion proteins. Understanding the normal and oncogenic role of these factors will be crucial for the design of therapeutic agents.

Publication types

  • Review

MeSH terms

  • Acetyltransferases / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Cell Transformation, Neoplastic*
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Chromatin / ultrastructure
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation
  • Histone Acetyltransferases
  • Histone Deacetylases / metabolism
  • Humans
  • Models, Biological
  • Mutation
  • Neoplasms / etiology*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Nucleosomes / metabolism
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism*
  • Receptors, Retinoic Acid / metabolism
  • Retinoid X Receptors
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Nucleosomes
  • Oncogene Proteins, Fusion
  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Adenosine Triphosphate
  • Acetyltransferases
  • Histone Acetyltransferases
  • Histone Deacetylases