Cellular Senescence as a Tumor-Suppressor Mechanism

Trends Cell Biol. 2001 Nov;11(11):S27-31. doi: 10.1016/s0962-8924(01)02151-1.

Abstract

Organisms with renewable tissues had to evolve mechanisms to prevent the development of cancer. One such mechanism is cellular senescence, which irreversibly arrests the growth of cells at risk for neoplastic transformation. Recent findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cell Transformation, Neoplastic*
  • Cellular Senescence / genetics
  • Cellular Senescence / physiology*
  • Genes, Tumor Suppressor / physiology*
  • Genes, p53 / genetics
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / physiopathology
  • Phenotype
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism
  • Telomere / metabolism

Substances

  • Retinoblastoma Protein