Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation

Am J Kidney Dis. 2001 Nov;38(5):1105-7. doi: 10.1053/ajkd.2001.28617.


The use of herbal medicine has become increasingly popular in the United States. Hypericum perforatum (St. John's wort) is an herbal extract that is used widely as a folk remedy for depression. In this case report, we describe a kidney transplant recipient who developed marked reduction of cyclosporine therapeutic activity after the self-initiation of St. John's wort. Postulated mechanisms for the ability of this herbal extract to interact with pharmaceutical medications are presented, and the existing literature is reviewed.

Publication types

  • Case Reports

MeSH terms

  • Creatinine / blood
  • Cyclosporine / blood*
  • Cyclosporine / therapeutic use
  • Drug Interactions
  • Humans
  • Hypericum / adverse effects*
  • Immunosuppressive Agents / blood*
  • Immunosuppressive Agents / therapeutic use
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Phytotherapy*
  • Review Literature as Topic


  • Immunosuppressive Agents
  • Cyclosporine
  • Creatinine