Treatment of superior limbic keratoconjunctivitis by application of autologous serum

Cornea. 2001 Nov;20(8):807-10. doi: 10.1097/00003226-200111000-00006.


Purpose: To determine the efficacy of autologous serum drops in the treatment of superior limbic keratoconjunctivitis (SLK).

Methods: Twenty-two eyes of 11 patients were diagnosed with SLK. All eyes were treated with 20% diluted autologous serum eyedrops 10 times a day in addition to ongoing treatment of dry eye. Fluorescein and rose bengal staining scores, as well as subjective symptom gradings, were performed before and after 4 weeks of therapy.

Results: Nine of the 11 patients responded well to treatment (82%). The average rose bengal and fluorescein score improved ( p < 0.05), and there was subjective improvement.

Conclusion: Autologous serum application can be used as an alternative mode of therapy in SLK.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Blood*
  • Female
  • Fluorescein
  • Fluorophotometry
  • Humans
  • Keratoconjunctivitis / therapy*
  • Limbus Corneae
  • Middle Aged
  • Rose Bengal
  • Tears / metabolism


  • Rose Bengal
  • Fluorescein