Abstract
Iroquois homeoproteins are prepatterning factors that positively regulate proneural genes and control neurogenesis. We have identified a zebrafish Iroquois gene, irx1, which is highly homologous to Xenopus Xiro1, Gallus c-Irx1 and mouse Irx1. Expression of irx1 was initially detected at the bud stage. By 16 h post-fertilization (hpf), irx1 expression was exclusively limited to the prospective midbrain and hindbrain. By 24 hpf, irx1 expression was clearly detected in the acousticovestibual ganglia, tectum, tegmentum, cerebellum and rhombomere 1 but not in rhombomere 2 or mid-hindbrain boundary.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / embryology
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Brain / metabolism
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Cloning, Molecular
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Conserved Sequence
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Gene Expression Regulation, Developmental
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Homeodomain Proteins / chemistry
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Homeodomain Proteins / genetics*
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Molecular Sequence Data
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Sequence Homology, Amino Acid
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Transcription Factors / chemistry
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Transcription Factors / genetics*
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Zebrafish / embryology*
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Zebrafish / genetics*
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Zebrafish Proteins / genetics
Substances
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Homeodomain Proteins
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Irx1 protein, mouse
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Transcription Factors
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Zebrafish Proteins
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irx1a protein, zebrafish
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irx1b protein, zebrafish