Role of endothelin-1 in lung disease

Respir Res. 2001;2(2):90-101. doi: 10.1186/rr44. Epub 2001 Feb 22.


Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Endothelin-1 / chemistry
  • Endothelin-1 / physiology*
  • Graft Rejection
  • Humans
  • Lung / blood supply
  • Lung Diseases / physiopathology*
  • Lung Neoplasms / physiopathology
  • Lung Transplantation
  • Molecular Sequence Data
  • Respiratory Distress Syndrome / physiopathology
  • Respiratory Tract Diseases / physiopathology
  • Vascular Diseases / physiopathology


  • Endothelin-1