Posterior capsule opacification with AcrySof and poly(methyl methacrylate) intraocular lenses. Comparative study with a 3-year follow-up

J Cataract Refract Surg. 2001 Oct;27(10):1586-90. doi: 10.1016/s0886-3350(01)00998-1.


Purpose: To evaluate whether reports of reduced posterior capsule opacification (PCO) rates with AcrySof intraocular lenses (IOLs) are applicable to a mixed group of cataract patients in everyday surgical practice.

Setting: Department of Ophthalmology, Kärnsjukhuset, Skövde, Sweden.

Methods: A retrospective study comparing a study group receiving an AcrySof IOL (n = 145) and a group receiving a poly(methyl methacrylate) (PMMA) IOL (n = 153) was performed. The follow-up was 3 years in both groups. The performance of a neodymium:YAG laser capsulotomy was used as the end point for clinically significant PCO.

Results: Nine capsulotomies (6.2%) were performed in the AcrySof group and 34 (22.2%) in the PMMA group. The difference in the capsulotomy rate between the 2 groups was highly significant (P <.001). The relative risk was 3.6 times higher in the PMMA group.

Conclusions: There was a significant difference in the frequency of capsulotomy between AcrySof and PMMA IOLs in a mixed group of cataract patients in everyday clinical practice. This finding indicates the importance of the IOL type in PCO formation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / adverse effects*
  • Adult
  • Aged
  • Aged, 80 and over
  • Biocompatible Materials
  • Cataract / etiology*
  • Cataract / therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Laser Therapy
  • Lens Capsule, Crystalline / pathology*
  • Lens Capsule, Crystalline / surgery
  • Lens Implantation, Intraocular
  • Lenses, Intraocular / adverse effects*
  • Male
  • Middle Aged
  • Phacoemulsification
  • Polymethyl Methacrylate / adverse effects*
  • Retrospective Studies


  • Acrylic Resins
  • Biocompatible Materials
  • Polymethyl Methacrylate