ATM, a central controller of cellular responses to DNA damage

Cell Death Differ. 2001 Nov;8(11):1052-65. doi: 10.1038/sj.cdd.4400874.

Abstract

Mutations in the ATM gene lead to the genetic disorder ataxia-telangiectasia. ATM encodes a protein kinase that is mainly distributed in the nucleus of proliferating cells. Recent studies reveal that ATM regulates multiple cell cycle checkpoints by phosphorylating different targets at different stages of the cell cycle. ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNA double-strand breaks.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Ataxia Telangiectasia / pathology
  • Ataxia Telangiectasia / radiotherapy
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / metabolism
  • DNA Damage / physiology*
  • DNA Repair / physiology*
  • DNA-Binding Proteins
  • Genes, cdc / physiology
  • Humans
  • Protein Structure, Tertiary
  • Protein-Serine-Threonine Kinases / physiology*
  • Radiation Tolerance
  • Telomere / physiology
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein-Serine-Threonine Kinases