The CGA gene as new predictor of the response to endocrine therapy in ER alpha-positive postmenopausal breast cancer patients

Oncogene. 2001 Oct 18;20(47):6955-9. doi: 10.1038/sj.onc.1204739.


We recently identified CGA (coding for the alpha subunit of glycoprotein hormones) as a new estrogen receptor alpha (ER alpha)-responsive gene in human breast tumors. Here, we assessed the relationship between CGA status (as determined by real-time quantitative RT-PCR) and the response to tamoxifen therapy in a well-defined cohort of 125 ER alpha-positive postmenopausal breast cancer patients treated with primary surgery followed by adjuvant tamoxifen alone. CGA overexpression, observed in 37.6% of patients, was associated with good relapse-free survival (P=0.037; univariate analysis). CGA status, combined with ERBB2 status (a marker of poor outcome), was an independent predictor of the response to tamoxifen (P=0.020; multivariate analysis). CGA status, especially when combined with ERBB2 status, may thus provide useful predictive information on tamoxifen responsiveness in breast cancer.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / surgery
  • Chemotherapy, Adjuvant
  • Cohort Studies
  • Disease-Free Survival
  • Estrogen Antagonists / therapeutic use*
  • Estrogen Receptor alpha
  • Female
  • Genes
  • Glycoprotein Hormones, alpha Subunit / genetics
  • Glycoprotein Hormones, alpha Subunit / metabolism*
  • Humans
  • Middle Aged
  • Postmenopause
  • RNA, Neoplasm / biosynthesis
  • Receptor, ErbB-2
  • Receptors, Estrogen / analysis*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tamoxifen / therapeutic use*
  • Treatment Outcome


  • Antineoplastic Agents, Hormonal
  • Biomarkers, Tumor
  • Estrogen Antagonists
  • Estrogen Receptor alpha
  • Glycoprotein Hormones, alpha Subunit
  • RNA, Neoplasm
  • Receptors, Estrogen
  • Tamoxifen
  • Receptor, ErbB-2