Myostatin in muscle growth and repair

Exerc Sport Sci Rev. 2001 Oct;29(4):155-8. doi: 10.1097/00003677-200110000-00004.


Myostatin, a member of the TGF beta superfamily, regulates skeletal muscle size by controlling embryonic myoblast proliferation. Recent results show that myostatin may also have a role in muscle regeneration and muscle wasting of adult animals. This review summarizes the recent developments in the regulation of myostatin gene expression and mechanism of its function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Homeostasis / physiology
  • Humans
  • Muscle, Skeletal / embryology
  • Muscle, Skeletal / physiology*
  • Myostatin
  • Regeneration / physiology*
  • Transcription, Genetic
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / physiology*


  • MSTN protein, human
  • Myostatin
  • Transforming Growth Factor beta