Testosterone Attenuates Beta-Amyloid Toxicity in Cultured Hippocampal Neurons

Brain Res. 2001 Nov 16;919(1):160-5. doi: 10.1016/s0006-8993(01)03024-4.

Abstract

Accumulating evidence suggests that testosterone has neurotrophic and perhaps neuroprotective actions. Thus, age-related depletion of testosterone may increase the brain's vulnerability to Alzheimer's disease and related disorders. To begin investigating this issue, cultured neurons were exposed to the Alzheimer-related insult beta-amyloid in the presence of testosterone. beta-Amyloid neurotoxicity was significantly reduced by testosterone via a rapid, estrogen-independent mechanism. These data may provide additional insight into the treatment of age-related neurodegenerative disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloid beta-Peptides / toxicity*
  • Animals
  • Animals, Newborn
  • Cell Death / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Gonadal Steroid Hormones / pharmacology*
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Neurons / cytology
  • Neurons / drug effects*
  • Rats
  • Rats, Sprague-Dawley
  • Testosterone / pharmacology*

Substances

  • Amyloid beta-Peptides
  • Gonadal Steroid Hormones
  • Testosterone