Is the fatty meal a trigger for acute coronary syndromes

Atherosclerosis. 2001 Nov;159(1):9-15. doi: 10.1016/s0021-9150(01)00669-4.


This hypothesis paper aims to illustrate the role of fatty meal ingestion has on the vascular endothelium and coagulation system. In particular highlighting the potential risk of fatty meal ingestion both as a trigger to an adverse factor in patients with acute coronary syndromes. We propose that as a result of ingesting fatty meals as a part of daily living, there occurs a constellation of changes in the vasculature that results in both a hypercoagulable and a provasoconstrictor state. These acute changes in response to a fatty meal on endothelial function, prothrombosis, and platelet activation can potentially trigger, facilitate and propagate the forces that drive acute coronary syndromes. In type 2 diabetes, adverse postprandial phenomena are exaggerated and prolonged and may therefore be expected to contribute significantly to the excess risk of acute coronary syndromes and atherosclerotic development in these subjects.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Blood Coagulation / physiology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Dietary Fats / adverse effects*
  • Endothelium, Vascular / physiopathology
  • Humans
  • Lipids / blood
  • Lipids / physiology
  • Lipoproteins / physiology
  • Myocardial Ischemia / etiology
  • Myocardial Ischemia / physiopathology*
  • Platelet Activation
  • Postprandial Period
  • Thrombosis / physiopathology
  • Vasoconstriction / physiology


  • Dietary Fats
  • Lipids
  • Lipoproteins