Stem cells in tissue engineering

Nature. 2001 Nov 1;414(6859):118-21. doi: 10.1038/35102181.


The concept of producing 'spare parts' of the body for replacement of damaged or lost organs lies at the core of the varied biotechnological practices referred to generally as tissue engineering. Use of postnatal stem cells has the potential to significantly alter the perspective of tissue engineering. Successful long-term restoration of continuously self-renewing tissues such as skin, for example, depends on the use of extensively self-renewing stem cells. The identification and isolation of stem cells from a number of tissues provides appropriate targets for prospective gene therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Regeneration
  • Bone and Bones / cytology
  • Humans
  • Regeneration
  • Skin / cytology
  • Stem Cells*
  • Tissue Engineering* / trends