Regression of primary high-grade gastric B-cell lymphoma following Helicobacter pylori eradication

Eur J Gastroenterol Hepatol. 2001 Nov;13(11):1375-8. doi: 10.1097/00042737-200111000-00018.


The causative association between Helicobacter pylori and gastric mucosal inflammation is well established. The inflammatory process leads to the acquisition of mucosa-associated lymphoid tissue (MALT) by the stomach. Evidence links H. pylori gastritis with the development of low-grade primary gastric lymphoma with a phenotype specific for lymphoma of MALT type. It is now accepted that primary low-grade MALT lymphomas regress with H. pylori eradication therapy. However, the response of primary, diffuse, large-cell gastric lymphoma to H. pylori eradication therapy is still not established. We report a case of a primary high-grade gastric lymphoma regressing after H. pylori eradication therapy.

Publication types

  • Case Reports

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Aged
  • Female
  • Helicobacter Infections / complications*
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Lansoprazole
  • Lymphoma, B-Cell / etiology*
  • Lymphoma, B-Cell / pathology
  • Neoplasm Regression, Spontaneous*
  • Omeprazole / analogs & derivatives*
  • Omeprazole / therapeutic use
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / pathology


  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Lansoprazole
  • Omeprazole