Prevention of self-mutilation in patients with Lesch-Nyhan syndrome: review of literature

ASDC J Dent Child. May-Jun 2001;68(3):175-8.


There have been no standard methods established to prevent the self-mutilation seen in LNS. Preventive treatment must be developed, therefore, for each patient based on clinical findings. The first method to be utilized should be a nonsurgical splint or mouth guard. If it proves to be unsuccessful then the benefits of surgical procedures should be considered. In the future, the use of medication, such as carbamazepine, may prove to restructure the current approach advocated by the literature today.

Publication types

  • Review

MeSH terms

  • Antimanic Agents / therapeutic use
  • Carbamazepine / therapeutic use
  • Child, Preschool
  • Dental Care for Chronically Ill*
  • Female
  • Humans
  • Infant
  • Lesch-Nyhan Syndrome / complications*
  • Lesch-Nyhan Syndrome / diagnosis
  • Lip / injuries
  • Mouth Protectors
  • Occlusal Splints
  • Pregnancy
  • Prenatal Diagnosis
  • Restraint, Physical
  • Self Mutilation / etiology
  • Self Mutilation / prevention & control*
  • Tongue / injuries


  • Antimanic Agents
  • Carbamazepine