Expression of the MT1 melatonin receptor subtype in human coronary arteries

J Recept Signal Transduct Res. 2001 Feb;21(1):85-91. doi: 10.1081/rrs-100107144.


Previous experimental data suggest a possible influence of melatonin on the circulatory system of animals after binding to G-protein coupled melatonin receptors. The present study sought to investigate whether the melatonin receptor, mt1, is expressed in human coronary arteries derived from healthy heart donors (n = 8). Expression of the mt1-receptor was studied in sections of isolated coronary arteries by a reverse transcriptase-polymerase chain reaction (RT-PCR) and Western immunoblot technique. The analyses of the results from both methods indicated the presence of the mt1-receptor in all of the subjects. Referring to these data we assume that melatonin regulates physiological processes in human coronary arteries after receptor binding.

MeSH terms

  • Base Sequence
  • Blotting, Western
  • Coronary Vessels / metabolism*
  • DNA Primers / genetics
  • Gene Expression
  • Humans
  • Melatonin / metabolism
  • RNA / genetics
  • RNA / metabolism
  • Receptors, Cell Surface / classification
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Cytoplasmic and Nuclear / classification
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Melatonin
  • Reverse Transcriptase Polymerase Chain Reaction


  • DNA Primers
  • Receptors, Cell Surface
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Melatonin
  • RNA
  • Melatonin