Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 127 (2), 305-14

Epidemiology of Varicella Zoster Virus Infection in Canada and the United Kingdom


Epidemiology of Varicella Zoster Virus Infection in Canada and the United Kingdom

M Brisson et al. Epidemiol Infect.

Erratum in


Many countries are currently studying the possibility of mass vaccination against varicella. The objective of this study was to provide a comprehensive picture of the pre-vaccine epidemiology of the varicella zoster virus (VZV) to aid in the design of immunization programs and to adequately measure the impact of vaccination. Population-based data including physician visit claims, sentinel surveillance and hospitalization data from Canada and the United Kingdom were analysed. The key epidemiological characteristics of varicella and zoster (age specific consultation rates, seasonality, force of infection, hospitalization rates and inpatient days) were compared. Results show that the overall epidemiology of varicella and zoster is remarkably similar between the two countries. The major difference being that, contrary to Canada, the epidemiology of varicella seems to be changing in the United Kingdom with an important decrease in the average age at infection that coincides with a significant increase in children attending preschool. Furthermore, differences exist in the seasonality between the United Kingdom and Canada, which seem to be primarily due to the school calendar. These results illustrate that school and preschool contact patterns play an important role in the dynamics of varicella. Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies.

Similar articles

See all similar articles

Cited by 104 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms


LinkOut - more resources