Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time

J Ethnopharmacol. 2001 Dec;78(2-3):139-43. doi: 10.1016/s0378-8741(01)00336-1.

Abstract

Ocimum sanctum fixed oil produced hypotensive effect in anaesthetised dog, which seems to be due to its peripheral vasodilatory action. The oil increased blood-clotting time and percentage increase was comparable to aspirin and could be due to inhibition of platelet aggregation. The oil also increased pentobarbitone-induced sleeping time in rats indicating probable inhibitory effect of oil towards cytochromic enzyme responsible for hepatic metabolism of pentobarbitone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antihypertensive Agents / pharmacology
  • Aspirin / pharmacology
  • Blood Coagulation / drug effects*
  • Blood Pressure / drug effects*
  • Dogs
  • Dose-Response Relationship, Drug
  • Hypnotics and Sedatives / pharmacology
  • Male
  • Mice
  • Pentobarbital / pharmacology
  • Plant Oils / pharmacology*
  • Rats
  • Rats, Wistar
  • Sleep / drug effects*

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antihypertensive Agents
  • Hypnotics and Sedatives
  • Plant Oils
  • ocimum oil
  • Pentobarbital
  • Aspirin