Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats

J Nutr. 2001 Nov;131(11):2951-6. doi: 10.1093/jn/131.11.2951.


Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean lecithin and L-serine by a transphosphatidylation reaction, and its effect on age-related memory impairment was evaluated in rats by the Morris water maze test. Continuous oral administration of SB-tPS (60 mg x kg(-1) x d(-1) for 60 d) to male aged rats (24-25 mo) significantly improved performance in the water maze escape test (P < 0.01 vs. control aged rats) similar to bovine brain cortex-derived phosphatidylserine, which restores cognitive function in patients with senile dementia. SB-tPS also increased acetylcholine release and the Na(+), K(+)-ATPase activity of the synaptosomes prepared from these aged rats to the level in young rats. The nootropic actions of SB-tPS in the present study can be partly explained by the changes in these biochemical activities.

MeSH terms

  • Acetylcholine / metabolism
  • Administration, Oral
  • Animals
  • Brain / drug effects*
  • Brain / enzymology
  • Brain / metabolism
  • Cholesterol / metabolism
  • Escape Reaction / drug effects
  • Male
  • Memory Disorders / drug therapy*
  • Phosphatidylserines / administration & dosage
  • Phosphatidylserines / therapeutic use*
  • Phospholipids / metabolism
  • Rats
  • Rats, Wistar
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Soybeans


  • Phosphatidylserines
  • Phospholipids
  • Cholesterol
  • Sodium-Potassium-Exchanging ATPase
  • Acetylcholine