Macromolecular complexes: SMN--the master assembler

Curr Biol. 2001 Oct 30;11(21):R862-4. doi: 10.1016/s0960-9822(01)00517-6.

Abstract

Recent studies indicate that the protein affected in spinal muscular atrophy, SMN, plays a role in the assembly of a number of macromolecular complexes that function in the nucleus, interacting with its partner proteins via their arginine- and glycine-rich domains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Coiled Bodies / metabolism
  • Cyclic AMP Response Element-Binding Protein
  • Muscular Atrophy, Spinal / etiology*
  • Nerve Tissue Proteins / metabolism*
  • Protein Binding
  • RNA Splicing
  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear / metabolism
  • Ribosomes / metabolism
  • SMN Complex Proteins
  • Spliceosomes / metabolism
  • Transcription, Genetic

Substances

  • Cyclic AMP Response Element-Binding Protein
  • Nerve Tissue Proteins
  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear
  • SMN Complex Proteins