Checkpoints: chromosome pairing takes an unexpected twist

Curr Biol. 2001 Oct 30;11(21):R865-8. doi: 10.1016/s0960-9822(01)00518-8.

Abstract

When meiotic cells complete S phase, homologous chromosomes pair, synapse and undergo recombination. A checkpoint protein is somehow required for meiotic chromosome pairing in C. elegans, thus providing a direct link between S phase and the rest of the meiotic program.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / cytology*
  • Caenorhabditis elegans Proteins*
  • Cell Cycle Proteins*
  • Checkpoint Kinase 2
  • Chromosome Pairing*
  • DNA Damage
  • DNA Replication
  • Meiosis*
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae Proteins*

Substances

  • Caenorhabditis elegans Proteins
  • Cell Cycle Proteins
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • Checkpoint Kinase 2
  • CHK-2 protein, C elegans
  • Protein-Serine-Threonine Kinases
  • RAD53 protein, S cerevisiae