Abstract
A 63-year-old female with stage IE diffuse large B-cell lymphoma developed reversible posterior leukoencephalopathy syndrome (RPLS) following CHOP chemotherapy, with typical clinical and radiological findings. RPLS is a rare neurological syndrome characterised by visual disturbances, seizures, headaches and altered conscious level which has been associated with malignant hypertension, pre-eclampsia and some drugs, including ciclosporin. It has not been previously reported following CHOP chemotherapy. Alternative treatment should be considered for patients who develop this rare complication.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Brain Diseases / chemically induced*
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects
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Female
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Headache / etiology
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Humans
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Lymphoma, B-Cell / drug therapy*
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Lymphoma, Large B-Cell, Diffuse / drug therapy*
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Middle Aged
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Occipital Lobe / pathology*
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Prednisone / administration & dosage
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Prednisone / adverse effects
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Seizures / etiology
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Syndrome
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Vincristine / administration & dosage
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Vincristine / adverse effects
Substances
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone