Pax6 lights-up the way for eye development

Curr Opin Cell Biol. 2001 Dec;13(6):706-14. doi: 10.1016/s0955-0674(00)00274-x.


Recent reports have exposed the temporal and spatial functions of the transcription factor Pax6 in the developing vertebrate eye. Pax6 is demonstrated to play essential roles in successive steps triggering lens differentiation while in the retina it functions to maintain multipotency and proliferation of retinal progenitor cells. These findings, together with the identification of Pax6 protein partners and downstream targets, pave the way for future work aimed to understand the molecular mechanism of eye development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eye / embryology*
  • Eye Proteins
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins / physiology*
  • Lens, Crystalline / embryology
  • Mice
  • Models, Biological
  • PAX6 Transcription Factor
  • Paired Box Transcription Factors
  • Repressor Proteins
  • Retina / embryology
  • Stem Cells / physiology


  • Eye Proteins
  • Homeodomain Proteins
  • PAX6 Transcription Factor
  • PAX6 protein, human
  • Paired Box Transcription Factors
  • Pax6 protein, mouse
  • Repressor Proteins