Regulatory mechanisms in the pathways of cartilage and bone formation

Curr Opin Cell Biol. 2001 Dec;13(6):721-7. doi: 10.1016/s0955-0674(00)00276-3.


Three transcription factors of the Sox family have essential roles in different steps of the chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is needed for osteoblast differentiation, also stimulates hypertrophic chondrocyte maturation, it links the chondrocyte and osteoblast differentiation pathways in endochondral bone formation. Signaling molecules, including Indian Hedgehog, PTHrP and FGFs, also establish essential links either between these pathways, between steps in these pathways or between signaling molecules and transcription factors, so that a more comprehensive view of endochondral bone formation is emerging.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone and Bones / embryology*
  • Cartilage / embryology*
  • Cell Differentiation
  • Chondrocytes / physiology
  • Chondrogenesis*
  • Growth Plate / anatomy & histology
  • Growth Plate / embryology
  • Humans
  • Mesoderm / physiology
  • Mice
  • Models, Biological
  • Osteogenesis*
  • Signal Transduction
  • Transcription Factors / physiology


  • Transcription Factors