Asymptomatic brugada syndrome case unmasked during dimenhydrinate infusion

J Cardiovasc Electrophysiol. 2001 Oct;12(10):1192-4. doi: 10.1046/j.1540-8167.2001.01192.x.


Typical ECG of that described for Brugada syndrome was elicited in a patient diagnosed with labyrinthopathy during infusion of dimenhydrinate, a first-generation antihistamine usually used to treat motion sickness. Although the patient had no history of syncope or palpitations, and there was no family history of cardiac disease or sudden death, the ECG abnormality was reproduced later with intravenous flecainide, and an asymptomatic Brugada syndrome was diagnosed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bundle-Branch Block / chemically induced*
  • Bundle-Branch Block / diagnosis
  • Dimenhydrinate / administration & dosage*
  • Dimenhydrinate / adverse effects*
  • Electrocardiography
  • Histamine H1 Antagonists / administration & dosage*
  • Histamine H1 Antagonists / adverse effects*
  • Humans
  • Infusion Pumps*
  • Male
  • Syndrome
  • Tachycardia, Ventricular / chemically induced*
  • Tachycardia, Ventricular / diagnosis


  • Histamine H1 Antagonists
  • Dimenhydrinate