A new approach to decoding life: systems biology

Annu Rev Genomics Hum Genet. 2001:2:343-72. doi: 10.1146/annurev.genom.2.1.343.


Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The emergence of systems biology is described, as are several examples of specific systems approaches.

Publication types

  • Review

MeSH terms

  • Animals
  • Databases, Genetic*
  • Human Genome Project*
  • Humans