The role of polygalacturonase-inhibiting proteins (PGIPs) in defense against pathogenic fungi

Annu Rev Phytopathol. 2001;39:313-35. doi: 10.1146/annurev.phyto.39.1.313.

Abstract

Polygalacturonase-inhibiting proteins (PGIPs) are extracellular plant proteins capable of inhibiting fungal endopolygalacturonases (PGs). Plants have evolved different PGIPs with specific recognition abilities against the many PGs produced by fungi. The genes encoding PGIPs are organized into families, and different members of each family may encode proteins with nearly identical characteristics but different specificities and regulation. PGIPs are typically induced by pathogen infection and stress-related signals. The recognition ability of PGIPs resides in their LRR (leucine-rich repeat) structure, where solvent-exposed residues in the beta-strand/beta-turn motifs of the LRRs are determinants of specificity. Manipulation of the primary structure of PGIPs is expected to generate more efficient PGIPs with novel recognition specificities to protect crop plants against pathogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Cell Wall
  • Fungi / growth & development*
  • Fungi / pathogenicity
  • Gene Expression Regulation, Plant
  • Immunity, Innate / genetics
  • Magnoliopsida / enzymology
  • Magnoliopsida / genetics*
  • Magnoliopsida / microbiology
  • Molecular Sequence Data
  • Plant Diseases / genetics*
  • Plant Diseases / microbiology
  • Plant Proteins / genetics*
  • Plant Proteins / metabolism
  • Polygalacturonase / metabolism
  • Proteins / genetics
  • Proteins / physiology
  • Sequence Homology, Amino Acid
  • Signal Transduction

Substances

  • PGIP protein, plant
  • Plant Proteins
  • Proteins
  • leucine-rich repeat proteins
  • Polygalacturonase