Cyclin' round the cell with Rac

Dev Cell. 2001 Aug;1(2):160-1. doi: 10.1016/s1534-5807(01)00029-6.

Abstract

New insight into how integrins stimulate cell cycle progression is provided by a recent paper showing that Rac is activated in endothelial cells plated on fibronectin, but not on laminin, and regulates translation of Cyclin D1 mRNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • Cyclin D1 / metabolism
  • Endothelium / cytology
  • Fibronectins / metabolism
  • Laminin / metabolism
  • Models, Biological
  • Phosphorylation
  • Protein Binding
  • Protein Biosynthesis
  • RNA, Messenger / metabolism
  • Transcription, Genetic
  • rac GTP-Binding Proteins / metabolism*
  • rac GTP-Binding Proteins / physiology*

Substances

  • Fibronectins
  • Laminin
  • RNA, Messenger
  • Cyclin D1
  • rac GTP-Binding Proteins