Abstract
New insight into how integrins stimulate cell cycle progression is provided by a recent paper showing that Rac is activated in endothelial cells plated on fibronectin, but not on laminin, and regulates translation of Cyclin D1 mRNA.
MeSH terms
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Animals
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Cell Cycle*
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Cyclin D1 / metabolism
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Endothelium / cytology
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Fibronectins / metabolism
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Laminin / metabolism
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Models, Biological
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Phosphorylation
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Protein Binding
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Protein Biosynthesis
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RNA, Messenger / metabolism
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Transcription, Genetic
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rac GTP-Binding Proteins / metabolism*
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rac GTP-Binding Proteins / physiology*
Substances
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Fibronectins
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Laminin
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RNA, Messenger
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Cyclin D1
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rac GTP-Binding Proteins