Prenatal exposure to magnetic field increases dopamine levels in the striatum of offspring

Clin Exp Pharmacol Physiol. 2001 Nov;28(11):884-6. doi: 10.1046/j.1440-1681.2001.03538.x.

Abstract

1. The putative effects of prenatal exposure to magnetic field (MF) have recently received much interest. In the present study, mice were exposed to a MF of 50 mT during gestation (0-19 days). 2. After the exposure was terminated, mothers and offspring were returned to normal laboratory conditions. We then determined changes in striatal levels of dopamine (DA) and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the offspring. 3. Our results indicate that prenatal exposure to MF increases levels of DA and DOPAC in the striatum at 4, 8 and 12 weeks postnatally.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Corpus Striatum / embryology
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Female
  • Fetus / metabolism
  • Magnetics / adverse effects*
  • Mice
  • Mice, Inbred C57BL
  • Pregnancy
  • Prenatal Exposure Delayed Effects*

Substances

  • 3,4-Dihydroxyphenylacetic Acid
  • Dopamine