Genomic analysis of MIC genes in rhesus macaques

Tissue Antigens. 2001 Sep;58(3):159-65. doi: 10.1034/j.1399-0039.2001.580303.x.


MIC genes map to the major histocompatibility complex (MHC) and are distantly related to MHC class I genes. Recently, MICA/MICB-like genes have been described in nonhuman primates. In Macaca mulatta, three MICA/B-like genes could be identified: Mamu-MIC1, Mamu-MIC2, and Mamu-MIC3. We show here the isolation and characterization of rhesus macaque cosmid clones which carry the Mamu-MIC2 and Mamu-MIC3 genes. Neither the MIC2- and MIC3-coding sequences nor respective flanking sequences can be aligned unambiguously to either the human HLA-MICA or -MICB subregions, although MIC2 was found at a similar distance to the BAT1 gene as known for MICB in human. Thus, the characteristics allowing for a classification of primate MIC genes as being of the MICA or MICB types appear to have evolved after the separation of humans and rhesus monkeys from a common ancestor. Furthermore, also Mamu-MICD-containing cosmids could be isolated. In contrast to Mamu-MIC2 and Mamu-MIC3, the Mamu-MICD gene and its flanking sequences are highly conserved and orthologous to the human MICD subregion.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human
  • Cosmids / genetics
  • Evolution, Molecular
  • Genes, MHC Class I*
  • Genetic Vectors
  • Genome
  • Genomic Library
  • HLA Antigens / genetics
  • Humans
  • Macaca mulatta / genetics*
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Sequence Analysis, DNA


  • HLA Antigens

Associated data

  • GENBANK/AJ291497
  • GENBANK/AJ291498
  • GENBANK/AJ291499
  • GENBANK/AJ291602
  • GENBANK/AJ295225
  • GENBANK/AJ299489
  • GENBANK/AJ299490
  • GENBANK/AJ299491
  • GENBANK/AJ299492
  • GENBANK/AJ299493
  • GENBANK/AJ299494
  • GENBANK/AJ299495
  • GENBANK/AJ299496
  • GENBANK/AJ299497
  • GENBANK/AJ299498
  • GENBANK/AJ299499
  • GENBANK/AJ299500
  • GENBANK/AJ299501
  • GENBANK/AJ299502
  • GENBANK/AJ299503
  • GENBANK/AJ300445
  • GENBANK/AJ311802
  • GENBANK/AJ311803