Human papillomavirus genotypes in rural Mozambique

Lancet. 2001 Oct 27;358(9291):1429-30. doi: 10.1016/S0140-6736(01)06523-0.


We studied the genotype distribution of cervical human papillomavirus (HPV) infections in an age-stratified sample of 262 women in Mozambique using the PGMYO9-PGMY11 primer system in a reverse line-blot strip-based assay with high sensitivity in type-specific amplification. Despite the low precision of the estimates, we found that HPV-16 was not the dominant type. Instead, HPV 35 was the most commonly identified genotype among HPV-positive women (16/96 [17%]) and women with cervical neoplasia (7/23 [30%]). Certain genotypes might have been under-detected in previous studies, and type-specific HPV distributions might vary across populations. Therefore, the estimated proportion of cervical neoplasia that could be prevented by an HPV-16-based vaccine could be lower than expected.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Genotype
  • Humans
  • Middle Aged
  • Mozambique / epidemiology
  • Papillomaviridae / genetics*
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / genetics
  • Prevalence
  • Rural Population
  • Tumor Virus Infections / epidemiology*
  • Tumor Virus Infections / genetics
  • Uterine Cervical Dysplasia / epidemiology
  • Uterine Cervical Dysplasia / genetics
  • Uterine Cervical Dysplasia / virology*