Self-administration of amphetamine analogues in rats

Pharmacol Biochem Behav. Mar-Apr 1975;3(2):229-33. doi: 10.1016/0091-3057(75)90152-5.

Abstract

In rats self-injecting amphetamine (0.25 mg/kg/injection) at a stable level during daily 3 hr sessions, three different amphetamine analogues )phenmetrazine, diethylpropion and fenfluramine) were substituted for amphetamine, one at a time on different experimental days. Phenmetrazine (1.0 mg/kg/injection) and diethylpropion (2.0 mg/kg/injection) were self-administered but not fenfluramine (in doses of 0.1, 0.5 and 2.0 mg/kg/injection). It is concluded that amphetamine, phenmetrazine and diethylpropion have reinforcing properties, whereas fenfluramine has not.

Publication types

  • Comparative Study

MeSH terms

  • Amphetamine / administration & dosage
  • Amphetamine / pharmacology*
  • Animals
  • Behavior, Animal / drug effects*
  • Conditioning, Operant / drug effects*
  • Diethylpropion / administration & dosage
  • Diethylpropion / pharmacology*
  • Dose-Response Relationship, Drug
  • Fenfluramine / administration & dosage
  • Fenfluramine / pharmacology*
  • Humans
  • Injections, Intravenous
  • Male
  • Models, Biological
  • Phenmetrazine / administration & dosage
  • Phenmetrazine / pharmacology*
  • Rats
  • Reinforcement, Psychology
  • Substance-Related Disorders
  • Time Factors

Substances

  • Fenfluramine
  • Amphetamine
  • Diethylpropion
  • Phenmetrazine