Calcium receptor and regulation of parathyroid hormone secretion

Rev Endocr Metab Disord. 2000 Nov;1(4):307-15. doi: 10.1023/a:1026570518919.

Abstract

The cloning of the CaR has made it possible to show definitively that the CaR is a critical mediator of the inhibitory effect of high Cao2+ on PTH secretion and parathyroid cellular proliferation. The receptor may also mediate the suppressive action of high Cao2+ on PTH gene expression, while its involvement in several other known actions of Cao2+ on parathyroid function remain to be examined. Alterations in CaR expression and/or function are clearly involved in hyper- and hypocalcemic disorders caused by inactivating or activating CaR mutations, respectively, and could contribute to the deranged Cao(2+)-sensing in primary and uremic secondary HPT. Finally, CaR activators offer promise as the first truly effective mode of medical therapy for these latter two conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / physiology*
  • Cloning, Molecular
  • Humans
  • Molecular Sequence Data
  • Parathyroid Hormone / genetics
  • Parathyroid Hormone / metabolism*
  • Signal Transduction / physiology

Substances

  • Calcium-Binding Proteins
  • Parathyroid Hormone