Depression and nicotine: preclinical and clinical evidence for common mechanisms

Curr Psychiatry Rep. 2001 Dec;3(6):470-4. doi: 10.1007/s11920-001-0040-z.


Updated findings on the relationship between nicotine and depression are presented. Clinical and preclinical research on nicotine use and depression suggests that nicotine may have some properties in common with antidepressants. Updated findings involve the comorbidity of smoking and major depressive disorder (MDD), the influence of depression during withdrawal on failure to quit smoking, the course of MDD without nicotine and the neurobiology of smoking and depression.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Comorbidity
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / epidemiology*
  • Humans
  • Nicotine / pharmacology*
  • Nicotine / therapeutic use*
  • Receptors, Cholinergic / drug effects
  • Receptors, Nicotinic / drug effects
  • Smoking / epidemiology*
  • Smoking Cessation


  • Antidepressive Agents
  • Receptors, Cholinergic
  • Receptors, Nicotinic
  • Nicotine