Over the last decade, the application of a spectrum of molecular techniques has begun to revolutionise our understanding of protective immune responses to ectoparasites and the targets for those responses. The catalogue of potential and actual protective antigens characterised in detail is slowly expanding. The validity of regarding such antigens as generic and capable of cross-species protection is being explored. The immune interactions between host and parasite are being studied at a molecular rather than cellular level. All this should contribute to the eventual development of a range of recombinant vaccines, though important scientific limitations remain. These range from the innate susceptibility of individual parasite species to immunological attack, which can only be assessed on a case by case basis, to our ability to produce the desired recombinant antigens and to elicit and maintain the necessary immunological responses.