[Good response in case of hepatocellular carcinoma with portal tumor thrombs--a case report of interdisciplinary local therapy]

Gan To Kagaku Ryoho. 2001 Oct;28(11):1704-7.
[Article in Japanese]


A 56-year-old male patient with chronic C type hepatitis had HCC which invaded right portal vein trunk (Vp3). In August 2000, we performed intrahepatic artery infusion chemotherapy with CDDP and 5-FU under subcutaneous interferon alpha treatment. In addition, we used chemoradiation therapy for portal tumor thrombus in HCC. As the result of such therapy, the size of HCC and portal tumor thrombus reduced and the level of PIVKA-II decreased. There were no side effects except fever due to interferon alpha treatment. In February 2001, we performed devascularization and RFA therapy for HCC in S7 of liver under laparoscope. The level of PIVKA-II was within the normal range. It is important to perform interdisciplinary therapy appropriate for the HCC status.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Carcinoma, Hepatocellular / drug therapy
  • Carcinoma, Hepatocellular / radiotherapy
  • Carcinoma, Hepatocellular / therapy*
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Hepatic Artery
  • Humans
  • Infusions, Intra-Arterial
  • Interferon-alpha / administration & dosage
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / radiotherapy
  • Liver Neoplasms / therapy*
  • Male
  • Middle Aged
  • Neoplastic Cells, Circulating / pathology
  • Portal Vein*
  • Radiotherapy Dosage
  • Venous Thrombosis / therapy*


  • Antineoplastic Agents
  • Interferon-alpha
  • Cisplatin