Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats

Asia Pac J Clin Nutr. 2001;10(3):233-7. doi: 10.1046/j.1440-6047.2001.00246.x.


D-Psicose (D-ribo-2-hexulose), a C-3 epimer of D-fructose, is present in small quantities in commercial carbohydrate complexes or agricultural products. Wistar male rats were fed experimental diets which consisted of 5% D-psicose, cellulose, D-fructose or D-glucose for 28 days. Abdominal adipose tissue weight was significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed a D-fructose and D-glucose diets, even though the four dietary groups were offered the same amount throughout the experimental period. Fatty acid synthase and glucose 6-phosphate dehydrogenase activities in the liver were significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed the D-fructose and D-glucose diets. However, lipoprotein lipase activities in the heart, soleus muscle and perirenal adipose tissue were the same. These results suggest that a supplement of D-psicose in the diet suppresses hepatic lipogenic enzyme activities. The lower abdominal fat accumulation in rats fed a D-psicose diet might result from lower lipogenesis in the liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen
  • Adipose Tissue / anatomy & histology
  • Animals
  • Fatty Acid Synthases / metabolism*
  • Fructose / administration & dosage*
  • Fructose / chemistry
  • Fructose / metabolism
  • Glucose / administration & dosage
  • Glucosephosphate Dehydrogenase / metabolism*
  • Liver / enzymology*
  • Male
  • Random Allocation
  • Rats
  • Rats, Wistar


  • psicose
  • Fructose
  • Glucosephosphate Dehydrogenase
  • Fatty Acid Synthases
  • Glucose