Remarkable Application of Serum EBV EBER-1 in Monitoring Response of Nasopharyngeal Cancer Patients to Salvage Chemotherapy

Ann N Y Acad Sci. 2001 Sep;945:73-9. doi: 10.1111/j.1749-6632.2001.tb03866.x.

Abstract

Nineteen consecutive patients with metastatic or recurrent nasopharyngeal cancer (NPC) receiving combination chemotherapy were monitored for EBV DNA in their serum. EBV DNA (EBER-1) concentration in serum was measured before, during, and after chemotherapy. Thirteen patients had additional multiple prechemotherapy readings. There was a significant lead time from first detection of serum EBER-1 to clinical recurrence in 62% of patients by a mean of 17.4 weeks (range: 8-74.5 weeks; mean = 28.2 weeks if confined to the 8 patients with significant lead time). The median EBER-1 concentration was significantly higher in those with distant metastasis as compared to those with loco-regional recurrence only (17,468 vs. 684 pg/mL serum; p = 0.046, Mann-Whitney U test). Among the 13 patients who responded to chemotherapy, 4 exhibited clinical complete remission (CR) who were only found in the group with EBER-1 DNA drop to background level, while the magnitude of EBER-1 drop did not discriminate partial remission (PR) and stable disease (SD) patients clearly. Subsequent profile of EBER-1 DNA showed concordance with clinical course of either continuous remission or later progression. EBER-1 DNA in serum can become a useful adjunctive surrogate marker to monitor chemotherapeutic response in NPC patients with distant metastasis or advanced local recurrence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Viral / blood
  • Herpesvirus 4, Human / genetics*
  • Humans
  • Monitoring, Physiologic
  • Nasopharyngeal Neoplasms / blood
  • Nasopharyngeal Neoplasms / drug therapy*
  • Nasopharyngeal Neoplasms / virology
  • RNA, Viral / blood*
  • Salvage Therapy*
  • Treatment Outcome

Substances

  • DNA, Viral
  • Epstein-Barr virus encoded RNA 1
  • RNA, Viral