A role for neuromedin U in stress response

Biochem Biophys Res Commun. 2001 Nov 23;289(1):225-8. doi: 10.1006/bbrc.2001.5945.


Neuromedin U (NMU) is a hypothalamic peptide that has been recently found to reduce food intake, but few is known about its other functions in the central nervous system. We here studied behavioral activities induced by an intracerebroventricular (ICV) administration of NMU in rats and mice. NMU increased gross locomotor activity, face washing behavior, and grooming. NMU-induced stress response was significantly abolished by pretreatment with an antagonist of corticotropin-releasing hormone (CRH), alpha-helical CRH (9-41) (alpha-hCRH), or anti-CRH IgG. NMU did not induce locomotor activity in CRH knockout mice. NMU that interacts anatomically and/or functionally with the CRH system is a novel physiological regulator of stress response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology
  • Corticotropin-Releasing Hormone / administration & dosage
  • Corticotropin-Releasing Hormone / antagonists & inhibitors
  • Corticotropin-Releasing Hormone / deficiency
  • Corticotropin-Releasing Hormone / genetics
  • Grooming / drug effects
  • Grooming / physiology
  • Injections, Intraventricular
  • Male
  • Mice
  • Mice, Knockout
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Neuropeptides / administration & dosage
  • Neuropeptides / pharmacology*
  • Neuropeptides / physiology
  • Rats
  • Rats, Wistar
  • Stress, Physiological / physiopathology*


  • Neuropeptides
  • neuromedin U
  • Corticotropin-Releasing Hormone