Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease

Arch Neurol. 2001 Nov;58(11):1803-9. doi: 10.1001/archneur.58.11.1803.


An international group of clinical and basic scientists participated in the Frontotemporal Dementia and Pick's Disease Criteria Conference at the National Institutes of Health in Bethesda, Md, on July 7, 2000, to reassess clinical and neuropathological criteria for the diagnosis of frontotemporal dementia (FTD). Previous criteria for FTD have primarily been designed for research purposes. The goal of this meeting was to propose guidelines that would enable clinicians (particularly neurologists, psychiatrists, and neuropsychologists) to recognize patients with FTD and, if appropriate, to expedite their referral to a diagnostic center. In addition, recommendations for the neuropathological criteria of FTD were reviewed, relative to classical neuropathology and modern molecular biology.

Publication types

  • Guideline
  • Practice Guideline
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / physiopathology
  • Dementia / classification
  • Dementia / diagnosis*
  • Dementia / pathology
  • Dementia / physiopathology
  • Diagnosis, Differential
  • Female
  • Frontal Lobe / pathology
  • Frontal Lobe / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Pick Disease of the Brain / diagnosis*
  • Pick Disease of the Brain / pathology
  • Pick Disease of the Brain / physiopathology
  • Temporal Lobe / pathology
  • Temporal Lobe / physiopathology*