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, 1 (5), 590-2

Regulated Intramembrane Proteolysis Takes Another Twist

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Regulated Intramembrane Proteolysis Takes Another Twist

S Huppert et al. Dev Cell.

Abstract

Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.

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Cited by 2 PubMed Central articles

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