Relationship between oral surgical and endodontic procedures and episodic cluster headache

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Nov;92(5):499-502. doi: 10.1067/moe.2001.116153.


Objective: We sought to evaluate the possible relationship between oral surgery and endodontic procedures and the subsequent appearance of cluster headache (CH) in 54 patients.

Study design: This study included 54 patients diagnosed and treated for episodic CH. The characteristics of pain, the extractions, and the endodontic procedures performed in the same or a contralateral quadrant were recorded and analyzed by using the chi-square test.

Results: Prior tooth extraction or endodontics had been performed in the pain-affected quadrant in 58% of cases and in the contralateral quadrant in 33%. The differences between quadrants were statistically significant. After the onset of pain, extractions were performed in the affected quadrant in 44% of patients.

Conclusions: Although the appearance of pain after dental extraction could suggest a relationship between damage to the nerve supply and the development of CH, the possibility that dental extraction and endodontics may have been performed in response to CH-related pain must also be taken into account. With respect to the differential diagnosis of pain, it is easy for CH to be misdiagnosed as dental pulp pain.

MeSH terms

  • Adult
  • Aged
  • Chi-Square Distribution
  • Cluster Headache / classification
  • Cluster Headache / etiology*
  • Cluster Headache / physiopathology
  • Female
  • Flushing / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Nasal Obstruction / physiopathology
  • Rhinitis / physiopathology
  • Root Canal Therapy*
  • Tears / metabolism
  • Time Factors
  • Tooth Extraction*